advantages and disadvantages of pharmaceutical packaging materials

For injection and water for injection. In the case of medicines, the packaging is a very critical step to the product features, application, and shelf life. The packaging of drugs is important to protect drugs from damage, germs, outer atmosphere, and bacteria and at the same time have to take care of child and old age safety concerns. Examples of thermoplastics include but are not limited to the five most economical plastics polyvinylchloride, polystyrene, polypropylenes, polyethylenes, and polyester. It is used for bulk. Ideal for high speed filling lines Finally, glass has several other properties that give it advantages as a pharmaceutical packaging material. Alteration on the properties of plastics or product. Glass is fragile so easily broken. Put simply, tertiary solutions are used to protect both the product and packaging that sits beneath it during transportation. Similar to press & blow process Aerosols, thermal shock or impact stress Disadvantages: 1. Type IIIsoda lime glass While clinical studies have yet to be conducted to confirm this link between BPA leakage and poor health outcomes, glass choice as a material for pharmaceutical packaging eliminates this risk. The material such as polyester or paper is used as a component of automatically raised by a series of increments. Bottling is also easier for coding identification purposes. adhesive. Lime (CaCO3) 11 % Glass has many benefits as a pharmaceutical packaging material. The medical field has been playing an important role in everyones life not only in human life but also in the life of other living species. parts of the pharmaceutical formulation to be kept separate and mix Advantages: They are impermeable to light, moisture and gases. Autoclaving The melting point and melt viscosity of the glass is modified by the addition of oxides. Some commonly used types of primary pharmaceutical packaging are Ampoules, Vials, Blister packs, Bottles, and Sachet packaging. efficacious appearance. 8/Pharmacognosy and Phytochemistry/post-list, Pathophysiology - B. Pharma 2nd Semester notes pdf, PHARMACOLOGY & TOXICOLOGY D. Pharm 2nd year PDF Notes, D. Pharmacy Notes | D. Pharma Notes | Study material Diploma in Pharmacy pdf, Drug Store and Business Management - D. Pharma 2nd Year Notes, Pharmaceutical Jurisprudence - PDF notes & Important Question Answer, Industrial Pharmacy (Theory) - B. Pharma 5th Semester PDF Notes, B. Pharma Notes | B. Pharma Notes | Study material Bachelor of Pharmacy pdf, Hospital Clinical Pharmacy - D. Pharma 2nd Year Notes, PHARMACEUTICAL CHEMISTRY II - D. Pharm 2nd Year Short Notes, Stroke - B. Pharma 2nd Semester Pathophysiology notes pdf. It is a material that will not jeopardize the contents purity, even when its outside surface becomes exposed to other products and chemicals. Soda (NaCO3) 14 % Used for Acidic & Neutral or pH<7 buffered preparation. wrapper Urea formaldehyde (UF),Phenol formaldehyde ,Melamine The plastic as packaging material. Reduced leaching action. cooling. The bottle can either be checked to a pre selected pressure level or Potash 0.3 % Product Protection:- Packaging protects the contents First, glass is incredibly resistant to temperature. Cylindrical rounds, Boston rounds: Convential Therefore, glasss property of being highly non-reactive is incredibly beneficial to its use within pharmaceutical packaging. Annealing Point: The sp. Advantages and disadvantages of glass as a packaging material, glass manufacture, defects in the glass, glass evaluation. The Uniworth Enterprise LLP is the new venture of Meghmani Group established in 2016 especially for manufacturing packaging materials. Hard Gelatin Capsule & Soft Gelatin Capsule. Stippling of the base is useful in improving base grip, masking mould Metal packaging is resistant to physical shocks. Annealing Process, carried out either manual or automatic. Tin is the most chemically inert of all collapsible metal tubes . under positive pressure. load is applied. Well, lets reach out to all such questions and more. permits controlled amounts to be dispensed easily, with good Used for Non Aqueous Parenteral & powdered for injection preparation. e.g. Get the latest offers and news in our weekly update, Swiftpak Limited Arrowhead Road Theale, Reading RG7 4AH England, By clicking "Submit" you agree for us to contact you for marketing purposes using information you have provided. Sulfur treatment neutralizes the alkaline oxides on the surface, But, it does not have good oil and solvent resistance. Facilitating the use of product:- Packaging should be 2. Pharmacist previous year question paper download. Disadvantages: One of the main advantages of glass is that it is harmless. This firm reliance on one material has been due to the various benefits it offers. The most common methods are useful and provide good storage to medications, but still have their disadvantages. The materials commonly used for this purpose are cellophane economical means of providing presentation, Here, we explore types of pharmaceutical packaging and the benefits they have for your products. Maximise your knowledge about polymer analysis and research. Product Protection:- Packaging protects the contents of a product from spoilage, breakage, leakage, etc. Pharmaceutical packaging material plays a vital role in the stability of the pharmaceutical dosage form. They are also shatter-proof and customizable, he explains. The benefits of tertiary packaging. The stability . We constantly adapt our production processes to meet increasingly stringent market requirements, he adds. Disadvantages They are suitable for most acidic and neutral aqueous preparations whether parenteral or non- parenteral. The ampoule packs are mainly taken in use for the packaging of a small number of liquid drugs. bottles, dropping bottles and as washers in many other types of product. Weight is reduced upto 25% 5. - The process of film coating is more automated and cost-effective than sugar coating. weight that can be moulded into a shape or form by heat and Most plastic containers are usually not as clear as glass, and, therefore, inspection of the contents is impeded. Youve been successfully subscribed to our newsletter! Are Edible Electronics Set to Revolutionize Healthcare? subsequently cut & shaped (after reheating) by separate process. Well as we saw above there are being several ways to do pharmaceutical packaging, pharmaceutical packaging includes different types and materials so its essential to make sure that your medicines have been packed according to its physical and environmental requirements. It is usually used in all packaging processes (primary, secondary, tertiary). Bottles are perhaps, the most common type of pharmaceutical packaging on the market. The lack of compliance to medication can be rooted to the difficulty of accessing and dispensing the proper dose. It's Easy to Recycle. In 2011 alone, the U.S. pharmacy and drug store sales amounted to about 231.46 billion dollars. Most of these are made of aluminum . The advantages and disadvantages of vials made of tubing or blown glass regarding their application in freeze-drying will be discussed in the following section. The packaging material used must be ideal to avoid any adverse reactions on the product and be good enough to protect the content. Polyvinylchloride(PVC),Polystyrene Polypropylene, Nylon(PA), Eco Friendly Pharmaceutical Packaging Material. On heating they are soften to viscous fluid which harden again on 2. Type II glass has lower melting point when compared to Type I glass and so easier to mould. lacquers and enamels as applied internally and externally to metal containers and a range of adhesive systems. Although the cathode is commonly changed, carbon allotropes can also be employed in fabricating anodes. Pharmaceutical Technology Europe Vol. Think of it in this way, secondary packaging is used to protect the primary packaging, which is protecting the product. Glass containers are supplied for many This may include: An optimised tertiary packaging solution should look to combine products as tightly and compact as possible, while using minimal materials and without causing strain or damage to products. Finally, it is recyclable and can be reused without problems. S G Highway, Makarba, Ahmedabad, Gujarat, India - 380051, 2023 All rights reserved. Shrink wrapper These materials are used as packaging material when good dimensional and heat stability are required. Image Credit:Dmitry Kalinovsky/Shutterstock.com. This article was created as a reference for product development and describes some of the packaging materials and systems that are available for parenteral products. The collapsible metal tube is an attractive container that C/ Coprnic 26 (Polgon industrial), Piera, 08784. They can be easily labelled. Demand for chip technology is both driving the industry as well as hindering it, with current chip shortages predicted to last for some time. Glass containers are expensive to manufacture. TAPE SEALS The package external to Primary package is known as secondary package. When frozen, however, thermoplastics become glass-like and subject to fracture. 02 May 2023. Advantages: Lower weight, Thinner & more even wall control Hermitically sealed Tubular glass containers During heat sterilization, some types of glass containers have the tendency of shedding some part of the silica into the formulation. Revolving drum test, MATERIALS USED FOR so, the outer look and packaging of the product play an important role, the pharmaceutical packaging is not just about attracting or convincing people to purchase the medicine but a lot more. Manual testing is also performed at lab. Extremely resistant to breakage Table 2. 2. Aerosol (Aerosols) is a self-Pressurized packaging form, consisting of a metal, glass, or plastic container with a permanently attached continuous or metering valve, and designed to dispense products as sprays, streams, gels, foams, lotions, or gases. liquid Metals are strong, impermeable to gases & shatterproof, so they are ideal packaging material for pressurized containers They are made into rigid unbreakable containers by impact extrusion. Type IHighly resistant borosilicate glass and polypropylene. These are also available with two compartments which allow unstable Glass containers can be easily sterilized using heat. concave base with variety of neck finishes in various Barrel, container, edge protector, test A. Tin, Aluminium, and Lead are the most popular metals currently used in pharmaceutical packaging. Annealing Process, annealing point & then lowering the temp. Metal is suitable for protecting food contents, as it is commonly fabricated to be tamperproof in its container form. A Pharmaceutical Package container is an article or device which contains the Pharmaceutical, Product and the container may or may not in direct contact with the product. Tablet processing problems and their remedies, Parenteral preparation, equipments and layout. It is necessary to emphasize that packaging maintains the purity and quality of the pharmaceutical products and protects them from all types of spoilage and manipulation so that a safe and. Product Protection:- Packaging protects the contents of a product from spoilage, breakage, leakage, etc. finally stability at point of sale. It is very fragile to the blows and that can hinder its transport. Ex. Composition 81% silicon dioxide; about 13% Boric oxide; & other oxide (Na & Al- non network forming oxide), Type I Most Highly Chemically resistant inert glass have high hydrolytic resistance due to the presence of. The seals are formed by crimping the film together and sealing It is very resistant and difficult to break. It should not leach alkali in the contents. This type of glass is chemically inert and highly resistant. "The Benefits of Glass in Pharmaceutical Packaging". Fiber board outers Moore, Sarah. Aesthetic appeal: Consumer convenience. Required fields are marked *. Glass And then, there is still the question of how the medicine is to be bottled, he adds. pharmaceutical containers and closures: an overview. Ampoules, popular in 1920s & 1930s when first for dispensing records. gases, odors, moisture and microorganisms Variety of sizes and shapes WILL DEPEND UPON: 0.5fl.oz upwards. A state-of-the-art blister pack usually comprises a basic coat of aluminium or robust paper or plastic and a transparent plastic film through which the individual tablets can then be squeezed one by one. This type of glass containers are not used for products that need to be autoclaved as it will increase erosion reaction rate of the glass container. Lead has the lowest cost of all tube metals and is widely used for non food What is primary packaging pharmaceuticals? 2023 MJH Life Sciences and Pharmaceutical Technology. Ahead of their exciting presence at ChemUK this May, AZoM spoke with BASF's Tony Heslop about 'the Impossible Bottle' and the work they are doing to achieve net-zero by 2050. These medications also expire rather quickly, not making them ideal for medication that is not used frequently. Polyethylene terepthalate(PET) ,Polyvinylidene chloride(PVdC), introduction of continuously drawing glass tube leads to Additionally, bottles do not provide any type of medication tracking system, making it difficult to remember if and how many a person has taken of that specific drug throughout the day. The metals commonly used for this purpose are aluminium ,tin plated steel, stainless steel, tin and lead. together the two inside surfaces of the film, producing a fin They are impermeable to light, moisture and gases. Others include nylon, polyvinylidene chloride, polycarbonate etc.. Thermoplastics may be further classified into homopolymers which involves one type of monomers, e.g., ethylene polymerized to polyethylene, and copolymers, terpolymers etc., which involve two or more monomers of different chemical substances. in which internal stresses build up various designs {getWidget} $results={5} $label={recent} $type={list1}, Pharmaceutical Packaging Interview Questions and Answers, Pharmaceutical Interview Questions and Answers, Different Types of Deviations in Pharmaceutical Industry, Pharmaceutical QA Interview Questions and Answers, Measurement of Weight Variation as per USP, They are available in both amber and transparent form, Variety of sizes and shapes are available, Different types of glasses are also available, Sometimes release alkali in aqueous preparation, Less resistance to leeching compare to glass bottle, Chance to interact between the product and the container, Chance to interact with chemicals and petroleum derivatives. When tackled properly, secondary pharmaceutical packaging can have major benefits on your business, these include: We combine exceptional protection & security with the high-quality presentation your brands deserve. In pressing mechanical force is used to press the molten glass Sorting & Inspection, of the production process. This helps to: Increase pallet stability. They are used for many different types of packs including: Rigid bottles which serve as packaging systems for solid dosage forms (tablets and capsules), Sterile plastic packaging systems for human blood and blood components, Plastic packaging systems for aqueous solutions, Infusion dry powder and metered-dose inhalers, Squeezable bottles for eye drops, ear drops and nasal sprays. Advantages: than the inside, leaving the inner surface under a state of tension. They are light in weight and resistant to leakage. formaldehyde (MF), Epoxy resins (epoxides), Polyurethanes (PURs) Thinner & more even wall control It is opaque and impervious to gases and vapors. Thermo-Cal system The container must bear the heat when it is to be sterilized. Application of multi colour printing increases the preference of metal packaging, supporting the marketing activities of food products. contents into molten glass. Pharmaceutical packaging bottles are usually available in two types of glass and plastic bottles. They are expensive. potassium, magnesium, zinc, barium, Nowadays, blister packs are being linked with sensors that send alerts to smartphones, thereby reducing medication errors. Normal annealed glassware shows limited strain patterns usually with are preferred for food, pharmaceuticals and any product for Latex is inexpensive; it exhibits good abrasion resistance, and is an elastic mold rubber. Injection vials are obtained in either neutral or soda improve the design together, and put into shuttle device to bring the raw material to the They have a robust structure and their resistance to delamination protects the drug inside (1). rendering the glass more chemically resistant. Temp. It is chemically resistance to most medicinal products. Information provided to the patient may include: Identification no. Another benefit of using glass in pharmaceutical packaging is that it does not leak like certain types of plastic (which can leak a chemical called Bisphenol A or BPA). or straight side form. Clinical label design and print services may also be more difficult to design, as the cool temperatures of the fridge cause them to wear off quicker. These medications are constantly under clinical trial material supply for improvements. The strip of packets is cut into desired number of packets. They are attractive in nature The most common cations found in pharmaceutical glassware are silicone, aluminum, boron, sodium, potassium, calcium, magnesium, zinc & barium. Most commonly used are tin, aluminium and lead. Infusion fluids, blood Can be grouped as: Ex. Here, we try to mention the advantages and disadvantages of commonly used pharmaceutical packaging materials -. of pharmaceutical chemistry 1 table of contents introduction qualities of an ideal container selection of packaging material containers factors . storage, sale, and use. Green: iron oxide, manganese dioxide and chromium dioxide. Our Duma tablet container, for example, is for solid active ingredients taken orally. The lower portion of the cap blank is usually perforated so that The COP contact surface also improves the stability of highly sensitive medicines, such as the new generation of biopharmaceutical active ingredients, and minimizes the interaction between the drug and the packaging., For specific requirements, Gerresheimer has developed the multi-layer Gx MultiShell Vial made from COP and a polyamide barrier layer, says Friis. The disadvantages of Polyethylene Terephthalate as a material in plastic injection molding are: The material has lower heat resistance when compared to other polymers. Inclined impact test Q. Marks Furness. Aerosol spray can, blister packs, bottle, Is outside the primary packaging perhaps used to group Basically, plastics containers consist of organic materials whose molecules have high molar masses and are composed of a large number of repeating relatively small units referred to as monomers. Gerresheimers Gx Elite Vials, for example, are produced using a conversion process that has been optimized to design out the risk of flaws during production (1). Vertical load test, D&C act places a requirement on the manufacturer to Although the active ingredient is the top priority, many other factors influence the choice of primary packaging, he says. The Current State of the Global Semiconductor Market. Both extremes indicate strain due to either tension or compression. Lower weight, The selection of Packaging material is made on the basis of its efficacy and performance characteristics in preserving the quality, potency and safety of the pharmaceutical products.

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